This information is intended for US healthcare professionals.
T1D Risk
300K people are at increased risk of developing Stage 3 T1D1
There are many
patients with
presymptomatic (Stage 1 and 2) T1D
More than 300,000 people in the United States are in the presymptomatic stages of type 1 diabetes. Beta-cell destruction begins months to years before the onset of T1D symptoms; those at increased risk may not be aware.1,2
The lifetime risk of developing Stage 3 T1D is up to 15x higher than the general population for any first-degree relatives of current T1D patients3,4
If a father has T1D, the child’s risk is
1 in174
If a mother has T1D, the child’s risk is
1 in254*
If both parents have T1D, the child’s risk is
1 in104
*If the child was born before the mother turns 25 years old; if child was born after 25, risk is 1 in 100.4
A child’s risk is doubled if a parent developed Stage 3 T1D before age 11.4
Knowing what to look for and how T1D progresses in patients is the first step in the future of care
1. Ward K, Pan C, Shinde M, Rievathavorn J, Hedge S, Gaebler JA; JDRF. Modeling the total economic value of novel type 1 diabetes (T1D) therapeutic concepts. Published January 2020. Accessed December 2, 2022. https://t1dfund.org/wp-content/uploads/2020/02/Health-Advances-T1D-Concept-Value-White-Paper-2020.pdf
2. Ziegler AG, Rewers M, Simell O, et al. Seroconversion to multiple islet autoantibodies and risk progression to diabetes in children. JAMA. 2013;309(23):2473-2479.
3. Couper JJ, Haller MJ, Greenbaum CJ, et al. ISPAD Clinical Practice Consensus Guidelines 2018: stages of type 1 diabetes in children and adolescents. Pediatr Diabetes. 2018;19(suppl 27):20-27.
4. American Diabetes Association. Learn the genetics of diabetes. Accessed December 2, 2022. https://www.diabetes.org/diabetes/genetics-diabetes