This information is intended for US healthcare professionals.
More than 300,000 people in the United States are in the presymptomatic stages of type 1 diabetes. Beta-cell destruction begins months to years before the onset of T1D symptoms; those at increased risk may not be aware.1,2
If a father has T1D, the child’s risk is
If a mother has T1D, the child’s risk is
If both parents have T1D, the child’s risk is
*If the child was born before the mother turns 25 years old; if child was born after 25, risk is 1 in 100.4
1. Ward K, Pan C, Shinde M, Rievathavorn J, Hedge S, Gaebler JA; JDRF. Modeling the total economic value of novel type 1 diabetes (T1D) therapeutic concepts. Published January 2020. Accessed December 2, 2022. https://t1dfund.org/wp-content/uploads/2020/02/Health-Advances-T1D-Concept-Value-White-Paper-2020.pdf
2. Ziegler AG, Rewers M, Simell O, et al. Seroconversion to multiple islet autoantibodies and risk progression to diabetes in children. JAMA. 2013;309(23):2473-2479.
3. Couper JJ, Haller MJ, Greenbaum CJ, et al. ISPAD Clinical Practice Consensus Guidelines 2018: stages of type 1 diabetes in children and adolescents. Pediatr Diabetes. 2018;19(suppl 27):20-27.
4. American Diabetes Association. Learn the genetics of diabetes. Accessed December 2, 2022. https://www.diabetes.org/diabetes/genetics-diabetes